Scientific publications

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines

Marijke W. A. Molenaar‑de Backer, Paulien Doodeman, Fereshte Rezai, Lisa M. Verhagen, Arno van der Ark, Els M. Plagmeijer, Bernard Metz, Naomi van Vlies, Olga Ophorst & René H. M. Raeven

Mass Spectrometry-Based Quantification of the Antigens in Aluminum Hydroxide-Adjuvanted Diphtheria-Tetanus- Acellular-Pertussis Combination Vaccines

Larissa van der Maas, Maarten Danial, Gideon F. A. Kersten, Bernard Metz and Hugo D. Meiring

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Marieke Hoonakker

Degradomics-Based Analysis of Tetanus Toxoids as a Quality Control Assay

Thomas J. M. Michiels, Wichard Tilstra, Martin R J Hamzink, Justin W de Ridder, Maarten Danial, Hugo D Meiring, Gideon F A Kersten, Wim Jiskoot, Bernard Metz

Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development

Thomas J. M. Michiels, Christian Schöneich, Martin R J Hamzink, Hugo D Meiring, Gideon F A Kersten, Wim Jiskoot, Bernard Metz

Safety testing of acellular pertussis vaccines: Use of animals and 3Rs alternatives

Marieke Hoonakker , Juan Arciniega, Coenraad Hendriksen

Drivers and barriers in the consistency approach for vaccine batch release testing: Report of an international workshop

Martijn W P Bruysters, Marie-Jeanne Schiffelers, Marieke Hoonakker, Carmen Jungbaeck, Ian Ragan, Eddy Rommel, Ton van der Stappen, Laura Viviani, Ellen V Hessel, Arnoud M Akkermans, Rob J Vandebriel

The Isolated Chicken Eye test to replace the Draize test in rabbits

Menk K Prinsen, Coenraad F M Hendriksen, Cyrille A M Krul, Ruud A Woutersen Biologicals

Reporter cell lines for detection of pertussis toxin in acellular pertussis vaccines as a functional animal-free alternative to the in vivo histamine sensitization test

Marieke E Hoonakker, Lisa M Verhagen, Larissa van der Maas, Arjen Sloots, Coenraad F M Hendriksen

In search of acceptable alternatives to the murine histamine sensitisation test (HIST): what is possible and practical?

L Wagner, R Isbrucker, C Locht, J Arciniega, A Costanzo, R McFarland, H Oh, M Hoonakker, J Descamps, S R Andersen, R K Gupta, K Markey, J M Chapsal, K Lidster, W Casey, D Allen