Scientific publication

Outer membrane vesicle-based intranasal vaccines

Peter Van der Ley, Virgil EJC Schijns,

In vitro alternative for reactogenicity assessment of outer membrane vesicle based vaccines In

Marijke W. A. Molenaar‑de Backer, Paulien Doodeman, Fereshte Rezai, Lisa M. Verhagen, Arno van der Ark, Els M. Plagmeijer, Bernard Metz, Naomi van Vlies, Olga Ophorst & René H. M. Raeven,

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae

Yingru Liu, Laura A Hammer, Jikke Daamen, Michiel Stork, Nejat K Egilmez, Michael W Russell

Validation of an FFF-MALS Method to Characterize the Production and Functionalization of Outer-Membrane Vesicles for Conjugate Vaccines

Robert M F van der Put , Arnoud Spies, Bernard Metz, Daniel Some, Roger Scherrers, Roland Pieters, Maarten Danial

An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

Peter van der Ley, Afshin Zariri, Elly van Riet, Dinja Oosterhoff, Corine Kruiswijk

Vaccination with meningococcal outer membrane vesicles carrying Borrelia OspA protects against experimental Lyme borreliosis

PM J Klouwens, M L M Salverda, J J Trentelman, J I Ersoz, A Wagemakers, M J H Gerritzen, P A van der Ley, J W Hovius

Describing the pre-clinical data of the candidate Lyme vaccine based on Intravacc’s OMV platform, this study shows that OMV’s expressing Borrelia (lipo)proteins is a promising vaccine concept that might lead to protecting humans against Lyme disease. Currently, no vaccine against Lyme disease, the fastest growing and most common tick-borne illness in North America and Europe, is available for humans. Antibiotics are the primary treatment and are usually successful, but only when given in time. A vaccine would limit the use of antibiotics and the potential rise of antibiotic resistance. For more information, see also our press release  
 

Shortening the Lipid A Acyl Chains of Bordetella pertussis Enables Depletion of Lipopolysaccharide Endotoxic Activity

jesús Arenas, Elder Pupo, Coen Phielix, Dionne David, Afshin Zariri, Alla Zamyatina, Jan Tommassen, Peter van der Ley

Intranasal immunization with outer membrane vesicle pertussis vaccine confers broad protection through mucosal IgA and Th17 responses

René H M Raeven , Dedeke Rockx-Brouwer, Gaurav Kanojia, Larissa van der Maas, Tim H E Bindels, Rimko Ten Have, Elly van Riet, Bernard Metz

Continuous production of Neisseria meningitidis outer membrane vesicles

Matthias J H Gerritzen, Lilli Stangowez, Bas van de Waterbeemd, Dirk E Martens, René H Wijffels, Michiel Stork

Diphtheria toxoid dissolving microneedle vaccination: Adjuvant screening and effect of repeated-fractional dose administration

M Leone, S Romeijn, G Du, S E Le Dévédec, H Vrieling, C O'Mahony, J A Bouwstra, G Kersten