Scientific publications

Carriers and Antigens: New Developments in Glycoconjugate Vaccines

Robert M.F. van der Put, Bernard Metz, Roland J. Pieters

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

Dani Cohen , Jacob Atsmon, Cécile Artaud, Shiri Meron-Sudai, Marie-Lise Gougeon, Anya Bialik, Sophy Goren, Valeria Asato, Ortal Ariel-Cohen, Arava Reizis, Alexandra Dorman, Carla W G Hoitink, Janny Westdijk, Shai Ashkenazi, Philippe Sansonetti, Laurence A

The results of a clinical study with an experimental vaccine against Shigella, intestinal bacteria that cause severe diarrhea and dysentery. The paper was authored by a team of researchers and clinicians at Tel Aviv University, Tel Aviv Sourasky Medical Center, Institut Pasteur, Ariel University and Intravacc. The clinical study in healthy adults shows that the vaccine is well tolerated and immunogenic. Intravacc developed a production process for this conjugate vaccine, manufactured the GMP batch and did stability testing and batch release. For more information, see also our press release
 

The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella

Robert M F van der Put, Carolien Smitsman, Alex de Haan, Martin Hamzink, Hans Timmermans, Joost Uittenbogaard, Janny Westdijk, Michiel Stork, Olga Ophorst, Françoise Thouron, Catherine Guerreiro, Philippe J Sansonetti Armelle Phalipon, Laurence A Mulard

Process development of a New Haemophilus influenzae type b conjugate vaccine and the use of mathematical modeling to identify process optimization possibilities

Ahd Hamidi, Hans Kreeftenberg, Leo V D Pol, Saroj Ghimire, Luuk A M V D Wielen, Marcel Ottens

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

Robert M F van der Put, Tae Hee Kim, Catherine Guerreiro, Françoise Thouron, Peter Hoogerhout, Philippe J Sansonetti, Janny Westdijk, Michiel Stork, Armelle Phalipon, Laurence A Mulard

HPAEC-PAD quantification of Haemophilus influenzae type b polysaccharide in upstream and downstream samples

Robert M F van der Put, Alex de Haan, Jan G M van den IJssel, Ahd Hamidi, Michel Beurret

Use of immuno assays during the development of a Hemophilus influenzae type b vaccine for technology transfer to emerging vaccine manufacturers

Ahd Hamidi, Hans Kreeftenberg

Preclinical evaluation of a Haemophilus influenzae type b conjugate vaccine process intended for technology transfer

Ahd Hamidi, Pauline Verdijk, Hans Kreeftenberg

Lessons learned during the development and transfer of technology related to a new Hib conjugate vaccine to emerging vaccine manufacturers

A Hamidi, C Boog, S Jadhav, H Kreeftenberg

HPAEC-PAD method for the analysis of alkaline hydrolyzates of Haemophilus influenzae type b capsular polysaccharide

Alex de Haan , Robert M. F. van der Put and Michel Beurret