Scientific publications

Lipid A heterogeneity and its role in the host interactions with pathogenic and commensal bacteria

Sukumar Saha, Elder Pupo, Afshin Zariri, Peter van der Ley

Aluminum Hydroxide And Aluminum Phosphate Adjuvants Elicit A Different Innate Immune Response

Sietske Kooijman, Hilde Vrieling, Lisa Verhagen, Justin de Ridder, Alex de Haan, Elly van Riet , Albert J.R. Heck, Gideon F.A. Kersten, Jeroen L.A. Pennings, Bernard Metz, Hugo D. Meiring

Activation of Canine, Mouse and Human TLR2 and TLR4 by Inactivated Leptospira Vaccine Strains

Andreja Novak, Elder Pupo, Esther Van't Veld, Victor P M G Rutten, Femke Broere, Arjen Sloots

The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella

Robert M. F. van der Put, Carolien Smitsman, Alex de Haan, Martin Hamzink, Hans Timmermans, Joost Uittenbogaard, Janny Westdijk, Michiel Stork, Olga Ophorst, Françoise Thouron, Catherine Guerreiro, Philippe J. Sansonetti, Armelle Phalipon, and Laurence A.

Nanoflow LC-MS Method Allowing In-Depth Characterization of Natural Heterogeneity of Complex Bacterial Lipopolysaccharides

Elder Pupo, Peter van der Ley, Hugo Meijring

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S

Thomas J M Michiels, Hugo D Meiring, Wim Jiskoot, Gideon F A Kersten, Bernard Metz

A great number of laboratory animals are still being used all over the world for the quality control of vaccines. This also applies for tetanus and diphtheria vaccines, both consisting of bacterial toxins inactivated by formaldehyde. This inactivation largely determines the quality of these vaccines. Researchers from Intravacc and LACDR have been searching for a test that reduces the use of laboratory animals. For more information, see our press release 
 

Hyaluronan molecular weight: Effects on dissolution time of dissolving microneedles in the skin and on immunogenicity of antigen

Mara Leone, Stefan Romeijn, Bram Slütter, Conor O'Mahony, Gideon Kersten, Joke A Bouwstra

Activation of Human Monocytes by Colloidal Aluminum Salts

Hilde Vrieling, Sietske Kooijman, Justin W de Ridder, Dominique M E Thies-Weesie, Peter C Soema, Wim Jiskoot, Elly van Riet, Albert J R Heck, Albert P Philipse, Gideon F A Kersten, Hugo D Meiring, Jeroen L Pennings, Bernard Metz

Skin delivery of trivalent Sabin inactivated poliovirus vaccine using dissolvable microneedle patches induces neutralizing antibodies

Agnese Donadei, Heleen Kraan, Olga Ophorst, Olivia Flynn, Conor O'Mahony, Peter C Soema, Anne C Moore

Stabilised aluminium phosphate nanoparticles used as vaccine adjuvant

Hilde Vrieling , Margarita Espitia Ballestas, Martin Hamzink, Geert-Jan Willems, Peter Soema, Wim Jiskoot, Gideon Kersten, Bernard Metz